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February 13, 2020February 13, 2020

Researchers Pinpoint Novel Genetic Variant as the Cause for LGS and Mild Intellectual Impairments in Korean Family

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A previously unknown inherited variation of a gene linked to Lennox-Gastaut Syndrome (LGS) was found as the underlying cause of the condition and mild intellectual disabilities in three generations ... Read more

February 6, 2020February 6, 2020

Distinct Mutations in Calcium Channel Gene May Lead to LGS, Study Suggests

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Distinct mutations in the CACNA1A gene — which contains instructions for producing a subunit of CaV2.1, a calcium channel key to nerve cell communication — are associated with Lennox-Gastaut ... Read more

January 30, 2020January 30, 2020

Christianson Syndrome Unexpectedly Identified as LGS Cause in Two Children, Case Study Reports

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Christianson syndrome, a genetic nervous system disorder not normally associated with Lennox-Gastaut syndrome (LGS), was unexpectedly found to be the underlying cause of LGS in two children, a case ... Read more

January 23, 2020January 23, 2020

FDA Approves Valtoco Nasal Spray for Treating Seizure Clusters

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The U.S. Food and Drug Administration (FDA) approved Neurelis’ Valtoco (diazepam nasal spray) as a rescue treatment for seizure clusters in people with epilepsy ages 6 and older. “Cluster or acute ... Read more

January 16, 2020January 16, 2020

Fycompa as Add-on Treatment Helps Lower Seizures in LGS Patients, Study Suggests

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Using Fycompa (perampanel) — an approved anti-seizure treatment for certain types of epilepsy — as an add-on therapy significantly reduced the frequency of seizures in adults with Lennox-Gastaut syndrome (LGS), ... Read more

January 9, 2020January 9, 2020

People With Late-Onset LGS May Maintain Their Cognitive and Functional Abilities, Study Finds

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People who start showing signs of Lennox-Gastaut syndrome later in life seem to be able to maintain their cognitive and functional abilities, a study has found. The results of ... Read more

January 2, 2020January 2, 2020

NHS Allows Adding Epidyolex, Cannabidiol Oral Solution, to Treat Lennox-Gastaut Patients in England

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Starting on Jan. 6, physicians in England will be able to prescribe the oral cannabidiol solution Epidyolex, in combination with clobazam, to treat persistent seizures in eligible people with ... Read more

December 19, 2019December 19, 2019

CBD Complements Clobazam to Prevent Seizures in Distinct Ways, Early Study Suggests

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Combining cannabidiol (CBD) with clobazam — a well-known treatment for childhood epilepsies like Lennox‑Gastaut syndrome (LGS) — leads to greater anti-seizure effects, but only when given at its therapeutic dose, ... Read more

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