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July 30, 2020July 30, 2020

No Evidence of Drug-Drug Interaction Between Clobazam, Epidiolex, Study Finds

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Epidiolex (cannabidiol) and clobazam showed no signs of adverse drug-drug interactions in treating people with epilepsy, according to the results of a recent Phase 2 study. The study, “A Phase ... Read more

July 23, 2020July 23, 2020

Cannabidiol Epidiolex Can Increase Diacomit Levels in Epilepsy Patients, Study Finds

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Using the cannabidiol Epidiolex in combination with Diacomit (stiripentol) or Depacon (sodium valproate) — two anti-epileptic treatments — does not seem to raise major safety concerns among patients with seizures ... Read more

July 16, 2020July 16, 2020

CBD Linked to More Side Effects in Epilepsy Patients Due to Interference With Other Medications

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Oral treatment with cannabidiol (CBD) is associated with a greater likelihood of adverse events and treatment withdrawal in children with rare forms of epilepsy, including those with Lennox-Gastaut syndrome, but ... Read more

July 9, 2020July 9, 2020

Report of Tongue Lesions Highlights Importance of Dental Check-ups in LGS

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Two individuals with Lennox-Gastaut syndrome (LGS) who had masses on their tongues, presumably as a result of tongue biting during seizures, were described in a new case report. These cases ... Read more

July 2, 2020July 2, 2020

Callostomy Using Lasers Appears to Ably Treat Drug-resistant Seizures in LGS

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A minimally invasive surgery using lasers to sever connections between the two halves of the brain can effectively and safely lower seizure frequency in people with Lennox-Gastaut syndrome (LGS) who ... Read more

June 25, 2020June 25, 2020

Oral CBD Epidyolex Reclassified as Over-the-counter Drug in UK

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The United Kingdom Home Office has reclassified Epidyolex (cannabidiol, or CBD) as a Schedule 5 drug, making it easier to obtain for patients with rare epileptic disorders such as Lennox-Gastaut ... Read more

June 4, 2020June 4, 2020

Mouse Model of LGS Created Based on Mutation Found in Patient

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Mice created with a single mutation found in a person with Lennox-Gastaut syndrome showed all the hallmarks of the condition, including the same seizure types, and were successfully treated with ... Read more

May 14, 2020May 14, 2020

Two New CHD2 Mutations Identified, Linked to LGS by Scientists

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Researchers have identified a number of previously unknown mutations in the CHD2 gene that are associated with several epileptic conditions, including Lennox-Gastaut syndrome (LGS), in children in China. The study, “CHD2‐related epilepsy: ... Read more

May 7, 2020May 7, 2020

Epidiolex Safely Lowers Seizure Frequency in Children, 3-Year Study Data Show

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When used alongside other anti-epileptic medications, Epidiolex (cannabidiol, CBD) safely reduces the frequency of seizures in children with Lennox-Gastaut syndrome (LGS), according to three-year data from a long-term extension study. ... Read more

April 16, 2020April 16, 2020

ET-101 Is Biologically Equivalent to Approved Topiramate Solid Products, Study Shows

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ET-101, Eton Pharmaceuticals’ proprietary topiramate oral solution shows similar properties and is biologically equivalent to the currently approved topiramate oral solid product, according to data from a bioequivalence study conducted ... Read more