Epidiolex (cannabidiol) and clobazam showed no signs of adverse drug-drug interactions in treating people with epilepsy, according to the results of a recent Phase 2 study. The study, “A Phase 2, Double‐Blind, Placebo‐Controlled Trial to Investigate Potential Drug‐Drug Interactions Between Cannabidiol and Clobazam,” was published…
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Using the cannabidiol Epidiolex in combination with Diacomit (stiripentol) or Depacon (sodium valproate) — two anti-epileptic treatments — does not seem to raise major safety concerns among patients with seizures caused by conditions such as Lennox-Gastaut syndrome (LGS), a Phase 2 study…
Oral treatment with cannabidiol (CBD) is associated with a greater likelihood of adverse events and treatment withdrawal in children with rare forms of epilepsy, including those with Lennox-Gastaut syndrome, but appears safe for other indications, a review of clinical trials shows. This is likely because childhood epilepsy patients…
Two individuals with Lennox-Gastaut syndrome (LGS) who had masses on their tongues, presumably as a result of tongue biting during seizures, were described in a new case report. These cases highlight the importance of regular dental examinations for people with LGS — particularly those who may have difficulty…
A minimally invasive surgery using lasers to sever connections between the two halves of the brain can effectively and safely lower seizure frequency in people with Lennox-Gastaut syndrome (LGS) who do not respond to medications, a study suggests. This surgery is relatively new, and seen as a potential option to…
The United Kingdom Home Office has reclassified Epidyolex (cannabidiol, or CBD) as a Schedule 5 drug, making it easier to obtain for patients with rare epileptic disorders such as Lennox-Gastaut syndrome. Epidyolex (known as Epidiolex in the U.S.) is an oral cannabidiol solution derived from the cannabis,…
Mice created with a single mutation found in a person with Lennox-Gastaut syndrome showed all the hallmarks of the condition, including the same seizure types, and were successfully treated with anti-epileptic medications, a study has found. This mouse strain represents a…
Researchers have identified a number of previously unknown mutations in the CHD2 gene that are associated with several epileptic conditions, including Lennox-Gastaut syndrome (LGS), in children in China. The study, “CHD2‐related epilepsy: novel mutations and new phenotypes,” was published in the journal Developmental Medicine & Child…
When used alongside other anti-epileptic medications, Epidiolex (cannabidiol, CBD) safely reduces the frequency of seizures in children with Lennox-Gastaut syndrome (LGS), according to three-year data from a long-term extension study. Findings were reported in an abstract, “Long-Term Safety and Efficacy of Cannabidiol (CBD) Treatment…
ET-101, Eton Pharmaceuticals’ proprietary topiramate oral solution shows similar properties and is biologically equivalent to the currently approved topiramate oral solid product, according to data from a bioequivalence study conducted in healthy volunteers. ET-101 is being investigated as a potential add-on therapy to manage seizures in…
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