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The U.S. Drug Enforcement Administration (DEA) has reclassified Epidiolex, an oral cannabidiol solution used to treat seizures, as a non-controlled substance, potentially easing patient access to it. This decision removes all federal controlled-substance restrictions for Epidiolex, which was approved in 2018 by the U.S. Food and Drug Administration (FDA)…

Oral treatment with pharmaceutical cannabidiol (CBD), sold under the brand Epidiolex, seems to be more effective to control seizures than artisanal preparations of CBD, in children and young patients with Lennox-Gastaut syndrome (LGS) and other epilepsies, a preliminary study has found. The difference in seizure control “is…

First, the bad news: If you’re one of the 30 million or so Americans with a rare disease, you probably have lower immunity to the novel coronavirus than most people. Now, the good news: You already know how to face loneliness and adversity — qualities that make you far stronger…

Spontaneous mutations affecting a critical protein produced in nerve and muscle cells, called EEF1A2, were found to be the underlying cause of Lennox-Gastaut syndrome (LGS) in two boys in China, a study reports.  Its authors recommended EEF1A2 mutations be evaluated in LGS…

The Living Rare, Living Stronger Patient and Family Forum, originally set for May 14–16 in Cleveland, Ohio, has been postponed until July 18–20 because of the coronavirus disease COVID-19 pandemic. The event’s sponsor, the National Organization for Rare Disorders (NORD),…

The ELEKTRA trial testing the investigational oral therapy soticlestat (OV935/TAK-935) in children with Lennox-Gastaut syndrome (LGS) and Dravet syndrome has completed patient enrollment, Ovid Therapeutics has announced. “We completed enrollment significantly ahead of schedule in our placebo-controlled Phase 2 ELEKTRA trial in children…

Banzel (rufinamide) — an approved add-on, anti-seizure oral therapy — is safe and effective in lowering seizure rates in children and adolescents with Lennox-Gastaut syndrome (LGS), according to a review study. Nevertheless, researchers point out that future studies are needed to better assess the therapy’s effectiveness and provide…

Following a ketogenic (high-fat, low-carb) diet may help reduce seizures and improve cognitive function in Lennox-Gastaut syndrome (LGS) patients with dysfunctional mitochondria, a small study from Korea suggests. The researchers highlighted patients’ difficulties in sticking to the diet, due to eating problems and gastrointestinal issues. That suggests there’s a…

Fintepla (ZX008), an investigational therapy from Zogenix, significantly lowered the frequency of drop seizures and was well tolerated in children and adults with Lennox‑Gastaut syndrome, according to topline results from a Phase 3 study. “We are pleased with the topline efficacy and safety results from Study 1601,…

Three adults with drug-resistant epilepsy, one of whom was diagnosed with Lennox-Gastaut syndrome (LGS), developed aspiration pneumonia — a potentially life-threatening lung infection — after starting treatment with the anti-seizure medication clobazam, according to a case report.