A previously unknown inherited variation of a gene linked to Lennox-Gastaut Syndrome (LGS) was found as the underlying cause of the condition and mild intellectual disabilities in three generations of a Korean family, according to a recent study. The findings were…
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Distinct mutations in the CACNA1A gene — which contains instructions for producing a subunit of CaV2.1, a calcium channel key to nerve cell communication — are associated with Lennox-Gastaut syndrome (LGS), a study suggests. Assessing the impact of these different CACNA1A mutations in CaV2.1’s function and location may…
Christianson syndrome, a genetic nervous system disorder not normally associated with Lennox-Gastaut syndrome (LGS), was unexpectedly found to be the underlying cause of LGS in two children, a case study reported. The study, “Epilepsy in Christianson syndrome:…
The U.S. Food and Drug Administration (FDA) approved Neurelis’ Valtoco (diazepam nasal spray) as a rescue treatment for seizure clusters in people with epilepsy ages 6 and older. “Cluster or acute repetitive seizures are challenging to treat and highly disruptive in the lives of people with epilepsy,”…
Using Fycompa (perampanel) — an approved anti-seizure treatment for certain types of epilepsy — as an add-on therapy significantly reduced the frequency of seizures in adults with Lennox-Gastaut syndrome (LGS), a recent study shows. Based on these data, researchers suggested that Fycompa be considered for LGS patients with…
People who start showing signs of Lennox-Gastaut syndrome later in life seem to be able to maintain their cognitive and functional abilities, a study has found. The results of the study, “Cognitive and functional status in late-onset Lennox–Gastaut syndrome: Variation on a classic phenotype,” were published in…
Starting on Jan. 6, physicians in England will be able to prescribe the oral cannabidiol solution Epidyolex, in combination with clobazam, to treat persistent seizures in eligible people with Lennox Gastaut syndrome (LGS)…
Combining cannabidiol (CBD) with clobazam — a well-known treatment for childhood epilepsies like Lennox‑Gastaut syndrome (LGS) — leads to greater anti-seizure effects, but only when given at its therapeutic dose, a preclinical study shows. These findings, which suggest that CDB has its own anti-seizure properties, may bring clarity to…
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