Approved Treatments for Lennox Gastaut Syndrome
Lennox-Gastaut syndrome (LGS) treatment is a unique journey for every patient. There is currently no cure for the condition and, as it involves various types of seizures and developmental challenges, doctors often use different strategies at once to help limit seizure activity. Today, there are a variety of LGS treatment options. Anti-seizure medications (ASMs) for LGS serve as the foundation of care for most patients.
Banzel
Banzel (rufinamide) is an oral medication used as an add-on treatment to help control seizures in people with Lennox-Gastaut syndrome. It works by adjusting the activity of sodium channels, which helps to manage the excessive nerve cell activity that causes seizures.
Clobazam
Clobazam is an approved add-on medication for managing seizures in people with Lennox-Gastaut syndrome (LGS). It belongs to a class of drugs called benzodiazepines, which affect calming signals in the brain. This helps reduce the excessive nerve cell firing that can cause seizures.
Epidiolex
Epidiolex is an oral therapy containing cannabidiol, a nonintoxicating part of the cannabis plant. The medication is approved to treat seizures in Lennox-Gastaut syndrome. It’s thought to help control abnormal brain activity that causes seizures, possibly by affecting calcium levels in brain cells.
Felbatol
Felbatol is an oral medicine used as an add-on treatment for seizures in children with Lennox-Gastaut syndrome when other therapies haven’t worked. The medication is thought to reduce brain chemical signaling that causes seizures, though its exact workings are not fully understood.
Fintepla
Fintepla is an oral medication approved to treat seizures in people ages 2 and older with Lennox-Gastaut syndrome. It is thought to work by changing serotonin levels and activity in the brain, which may help calm the overactive nerve signals that cause seizures.
Lamotrigine
Lamotrigine is an oral medication approved as an add-on treatment for seizures in people with Lennox-Gastaut syndrome. It works by inhibiting certain sodium channels on nerve cells, which helps prevent the abnormal electrical signals in the brain that lead to seizures. It is available under brand names like Lamictal and Subvenite, and also as generics.
Topiramate
Topiramate is an oral therapy approved as an add-on treatment for managing seizures associated with Lennox-Gastaut syndrome (LGS).
Klonopin
Klonopin (clonazepam) is an approved oral medication that’s used alone or as an add-on to control seizures in people with Lennox-Gastaut syndrome (LGS). It works by putting the brakes on excessive nerve cell firing that causes seizures. Klonopin belongs to a class of medications called benzodiazepines, which boost inhibitory brain signaling.
